Download Handbook of the Hemopoietic Microenvironment by John J. Trentin (auth.), Mehdi Tavassoli (eds.) PDF

By John J. Trentin (auth.), Mehdi Tavassoli (eds.)

In 1868, Ernst Neumann well-known that blood cells re­ quire non-stop replenishment in the course of postnata1life. ahead of him, the idea used to be that cells of the blood, like nerves as soon as shaped within the embryo, stay within the physique all through lifestyles. Neumann additionally well-known that this procedure happened in the bone marrow, simply because this tissue supplied a fa­ vorable setting for proliferation and differentiation of blood mobile precursors. Vera Danchakoff, the Russian embryologist operating within the US, in 1916 made an analogy to the soil and the seed. Bone marrow types the soil, supplying a good setting for the expansion of seed, the hemopoietic stem cellphone, and different progenitor cells. think within the distant prior a heap of comparable tree seeds. those seeds advance in our average weather right into a tall and lots of branched tree. consider the wind bears part of the seeds away and brings them to a land owning varied environmental stipulations, we are going to say the arc­ tic lands. There the seeds might enhance yet they could professional­ duce bushes no larger than our moss.

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38 proposed in 1964 a 'stochastic' model of CFU-S selfrenewal (birth) or differentiation (death) based solely on numbers of CFU-S detected in 10-d-old and 12-d-old spleen colonies on retransplantation. The numbers of CFU-S per colony were very heterogeneous and fitted a 'gamma' distribution better than a Poisson distribution. They set up a Monte Carlo chance model with any given cell division of the original CFU-S and its self-renewed CFU-S progeny having an arbitrary 60% chance of self-renewal (producing two CFU-S) and a 40% chance of death (producing only terminally differentiated progeny).

Sig. 05 No. Mice No. Col. Percent Ery. Gran. M. M. M. M. M. Spleen aAfter Wolf, N. , Jenkins, V. , and Trentin, J. J. (1972) Exper. Hematol. 22,37,38. bDonor and recipient mice were 3-4-mo-old (C57 BL6 x A)Fl hybrids maintained in a specific pathogen-free colony. Spleens were removed for examination 8 d after irradiation and hemopoietic cell transplantation. '5 x lQ4 bone marrow cells or 5 x lOS spleen cells were injected via the lateral tail vein. colony types in spleen vs marrow by 2-1 /2 h of residence in the marrow of an intermediate mouse, and the spleen stroma is more conducive to the growth of an erythroid-committed CFUS into an erythroid hemopoietic colony than is the marrow stroma.

Controls 20 Polycythemic 20 Group Mean No. b Neut. b Meg. b 378 377 Total undiff. Table 7 Survey of All Types of Microscopically Identifiable 8-Day Colonies in the Spleens of Control and Polycythemic Mice Receiving 900 Rand 12 x 1Q4 Isologous Marrow Cells" = ;;" ~ ~ ..... N N Historical Perspective 23 the same spleen were developing into granuloid or megakaryocyte colonies! In additional experiments in which erythropoietin was administered to polycythemic mice during only the last 4 d of colony growth, these tiny, undifferentiated colonies were converted into intermediate-sized pan-erythroid colonies containing up to 100,000 cells in all stages of erythropoiesis (see Fig.

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