Download Advances in Gene Delivery Systems by Kenya Kamimura; Takeshi Suda; Guisheng Zhang; Dexi Liu PDF

By Kenya Kamimura; Takeshi Suda; Guisheng Zhang; Dexi Liu

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LP is composed of a highly irritating mixture of hydroxylammonium nitrate, triethanolammonium nitrate and water. There was concern that skin exposure to this irritating mixture of chemicals compromised the barrier properties of skin, resulting in enhancement of its own penetration. When a penetrant is composed of a mixture of chemicals, it is much more difficult to assess changes in its skin penetration by using traditional chromatography methods to measure diffusion of the test article into and through skin layers.

However, if a substance cannot reach the viable layers of the skin, irritation will not result. If we can identify which factors are the most important for predicting skin penetration potential, we will establish some of the necessary conditions for toxic events subsequent to penetration of the barrier layer. In previous work, we firmly established pig skin as predictive of human skin absorption. Building on this data base, we developed a promising empirical relationship between penetration, molecular weight and vapor pressure for organic molecules applied to skin in volatile solvents.

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