Download Adult Leukemias 1 by Robert C. Gallo, Flossie Wong-Staal, Francis Ruscetti PDF

By Robert C. Gallo, Flossie Wong-Staal, Francis Ruscetti (auth.), Clara D. Bloomfield (eds.)

Where do you start to seem for a contemporary, authoritative article at the analysis or administration of a selected malignancy? The few normal oncology textbooks are in most cases outdated. unmarried papers in really expert journals are informative yet seldom entire; those are extra usually initial studies on a really constrained variety of sufferers. yes normal journals usually post solid indepth studies of melanoma themes, and pub­ lished symposium lectures are usually the simplest overviews to be had. Unfortu­ nately, those studies and vitamins seem sporadically, and the reader can by no means verify while a subject of exact curiosity should be coated. melanoma remedy and study is a sequence of authoritative volumes which target to satisfy this want. it really is an try to determine a serious mass of oncology literature overlaying almost all oncology subject matters, revised often to maintain the assurance brand new, simply on hand on a unmarried library shelf or by means of a unmarried own subscription. we now have approached the matter within the following type. First, by way of di­ viding the oncology literature into particular subdivisions equivalent to lung melanoma, genitourinary melanoma, pediatric oncology, and so on. moment, via asking eminent experts in every one of those parts to edit a quantity at the particular subject on an annual or biannual foundation. each one subject and tumor kind is roofed in a quantity showing usually and predictably, discussing present analysis, staging, markers, all varieties of therapy modalities, uncomplicated biology, and more.

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There are now several human one genes molecularly cloned and characterized (our unpublished data); simultaneous efforts are directed at studying expression of these genes in different cell types and characterization of the cellular one gene products in several laboratories, including our own. The next decade of research may provide some basic answers to the mechanisms of leukemogenesis in man. 6. SUMMARY AND CONCLUSIONS It seems increasingly important for people in leukemia research to have some interest and understanding of a major group of viruses, called retroviruses or RNA tumor viruses.

The above model of a cell both making and responding to TCGF may lead to uncontrolled proliferation. In turn. this may subsequently lead to an increase in the likelihood of mutational events which' fix ' the transformed state. Later in the progression of leukemogenesis. cells which express virus may be selected against by immune mechanisms. making finding them rare and difficult by the time of frank disease. 30 also respond to TCGF (Maeda and Gallo, unpublished). This is different from the normal situation where a subset of T -cells needs lectin/antigen stimulation plus an accessory cell to produce TCGF [134, 135].

Nature 244: 206-209, 1973. 109. Gallo RC, Gallagher RE, Miller NR, Mondal H, Saxinger WC, Mayer RJ, Smith RG, Gillespie DH: Relationships between components in primate RNA tumor viruses and in the cytoplasm of human leukemic cells: implications to leukemogenesis. In: Cold Spring Harbor Symposium on Quantitative Biology: tumor viruses. New York: Cold Spring Harbor Press, Vol 39, 1975, pp 933-961. 110. Jacquemin P, Saxinger C, Gallo RC: Surface antibodies of human myelogenous leukaemia leukocytes reactive with specific type-C viral reverse transcriptase.

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