By American Academy of Ophthalmology, Ramana S. Moorthy MD
Starts off with an outline of immune-mediated eye sickness, summarizing simple immunologic recommendations, ocular immune responses and specified issues in ocular immunology. Discusses the medical method of uveitis and stories noninfectious (autoimmune) and infectious different types of uveitis, with an accelerated part on viral uveitis and new fabric on infectious and noninfectious scleritis.
Enhanced detection of infectious brokers by way of immunologic and genetic equipment and biologic therapeutics are distinct. additionally covers endophthalmitis, masquerade syndromes, issues of uveitis and ocular elements of AIDS.
Upon of completion of part nine, readers can be capable to:
Identify normal and particular pathophysiologic methods that impact the constitution and serve as of the uvea, lens, intraocular cavities, retina, and different tissues in acute and persistent intraocular inflammation
Differentiate and establish infectious and noninfectious uveitic entities
Choose acceptable exam concepts and proper ancillary reports in line with even if an infectious or noninfectious reason is suspected
Read or Download 2014-2015 Basic and Clinical Science Course (BCSC): Section 9: Intraocular Inflammation and Uvetis PDF
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Extra info for 2014-2015 Basic and Clinical Science Course (BCSC): Section 9: Intraocular Inflammation and Uvetis
Advances in Ocular Immunology: Proceedings of the 6th International Symposium on the Immunology and lmmunopathology of the Eye. New York, NY: Elsevier; 1994:269272. Jett BD, Parke DW 2nd, Booth MC, Gilmore MS. Host/parasite interactions in bacterial endophthalmitis. Zentralbl Bakteriol. 1997;285(3):341-367. Killed lysates of many types of gram-positive bacteria or mycobacteria have been demonstrated to directly activate macrophages, making them useful as adjuvants. Some of these components have been implicated in various models for arthritis and uveitis.
3, Stimulated monocytes result from resting monocyte activation by other innate stimuli, without exposure to IFN-y. These cells are incompletely activated, producing low levels of cytokines and eicosanoids but not reactive oxygen intermediates. These cells participate in wound healing, angiogenesis, and low-level inflammatory reactions. DH = delayed hypersensitivity, LPS = lipopolysaccharide. / Resting monocytes express scavenging receptors of at least 3 types but synthesize very low levels of proinflammatory cytokines.
In animal studies, the toxin produced by as few as 100 Bacillus bacteria is capable of causing complete loss of retinal function in 12 hours. In addition to being directly toxic, bacterial exotoxins can also be strong triggers of innate immune response. 1 • CHAPTER 1: Basic Concepts in Immunology • 17 . Callegan MC, Jett BD, Hancock LE, Gilmore MS. Role ofhemolysin BL in the pathogenesis of extraintestinal Bacillus cereus infection assessed in an endophthalmitis model. Infect Immun. 1999;67(7):3357-3366.